Non-invasive estimation of left ventricular chamber stiffness using cardiovascular magnetic resonance and echocardiography.

ABSTRACT:

Background

Preclinical studies exploring the underlying mechanisms of elevated left ventricular (LV) chamber stiffness play a crucial role in developing new therapeutic strategies. However, there is a lack of systematic evaluation of imaging biomarkers of diastolic function against gold standard assessment of LV chamber stiffness in rodents. Therefore, we aimed to evaluate imaging biomarkers of diastolic function from cardiovascular magnetic resonance (CMR) and echocardiography in predicting the slope of the end-diastolic pressure-volume relationship (EDPVR) in rats.

Methods

Sprague Dawley rats with varying degrees of myocardial stiffness induced by aortic constriction (n=38) and healthy controls (n=9) underwent echocardiography and CMR at approximately 13 weeks post-operati

SUBMITTER: Hauge-Iversen IM 

PROVIDER: S-EPMC12182815 | biostudies-literature | 2025 Summer

REPOSITORIES: biostudies-literature