Simultaneous non-contrast assessment of cardiac microstructure and perfusion in vivo in the human heart.

ABSTRACT:

Background

Intravoxel incoherent motion (IVIM) imaging can provide information on cardiac microstructure and microvascular perfusion from a single examination. However, the spin echo-based approaches typically used for cardiac IVIM suffer from low sensitivity to changes in perfusion. The aim of this work was to develop a stimulated-echo (STEAM)-based method for IVIM and diffusion tensor cardiovascular magnetic resonance to simultaneously provide biomarkers of microstructure and perfusion in vivo in the human heart.

Methods

Here we introduce a novel STEAM-IVIM sequence incorporating phase cycling to obtain true non-diffusion weighted images (b = 0 s/mm²). STEAM-IVIM imaging was performed at 20 b-values (0 to 1000 s/mm²) to enable accurate estimation of t

SUBMITTER: Munoz C 

PROVIDER: S-EPMC12182817 | biostudies-literature | 2025 Summer

REPOSITORIES: biostudies-literature