Characterizing extravascular lung water-A dual-contrast agent extracellular volume approach by cardiovascular magnetic resonance.

ABSTRACT:

Background

Pathological extravascular lung water is a facet of decompensated congestive heart failure that current cardiovascular magnetic resonance (CMR) methods fail to quantify. CMR can measure total lung water density, but cannot distinguish between intravascular and extravascular fluid, and thus is not diagnostic. Therefore, we develop and evaluate a novel method to measure extravascular lung water by distinguishing intravascular from extracellular fluid compartments using two different contrast agents, extracellular gadolinium chelates and iron-based intravascular ferumoxytol.

Methods

We created two porcine models of pulmonary edema: reversible catheter-induced mitral regurgitation to induce extravascular lung water (n = 5); intravascular volume overload using rapid co

SUBMITTER: Seemann F 

PROVIDER: S-EPMC12182819 | biostudies-literature | 2025 Summer

REPOSITORIES: biostudies-literature