Association between hepatic steatosis index and impaired fasting glucose: a multicenter retrospective cohort study in China.

ABSTRACT:

Background

The Hepatic Steatosis Index (HSI) is a simple screening tool for adults with non-alcoholic fatty liver disease (NAFLD). While lipid and glucose metabolism are closely interrelated, few studies have examined the association between HSI and impaired fasting glucose (IFG). This study aims to investigate the relationship between HSI and IFG risk in a large Chinese cohort.

Methods

This retrospective cohort study analyzed health examination data collected from 2010 to 2016 across 11 cities in China by the Rich Healthcare Group. Multivariable Cox regression and restricted cubic spline (RCS) analyses were used to evaluate the association between baseline HSI and IFG. Subgroup analyses were conducted to assess the robustness of the findings.

Results

A total of 75,91

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12183071 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature