Transcriptome-wide association study of alternative polyadenylation identifies susceptibility genes in non-small cell lung cancer.

ABSTRACT: Alternative polyadenylation (APA) plays a crucial role in cancer development and prognosis. However, the molecular characteristics of APA related to non-small cell lung cancer (NSCLC) susceptibility remain understudied, especially in East Asian populations. In this study, we constructed an atlas of APA-regulated 3' untranslated region (3'UTR) and profiled its genetic regulation in 747 lung tissue samples (including tumors and paired normal tissues) from 417 NSCLC Chinese patients. We verified a significant global shortening of 3'UTRs in tumor samples compared to normal samples and underscored the value of APA-regulation as a prognostic marker. The 3'UTR APA quantitative trait loci (3'aQTL) was identified by regressing the percentage of distal poly(A) site usage index (PDUI) value on geneti

SUBMITTER: Xu X 

PROVIDER: S-EPMC12183086 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature