Regulation of nucleotide excision repair by wild-type HRAS signaling in head and neck cancer.

ABSTRACT: Head and neck squamous cell carcinoma (HNSCC) is characterized by a high rate of locoregional or distant relapse among patients. It is well established that resistance to chemotherapeutic drugs has an important role in the emergence of the recurrent and/or metastatic type of this malignancy which is associated with poor prognosis. Therefore, understanding the molecular basis of chemoresistance in head and neck cancer is required for the development of effective therapeutic strategies. Activating mutations in the HRAS gene are driver events in human cancer. Although numerous studies have demonstrated that oncogenic HRAS mutations promote chemoresistance in HNSCC, the molecular profile of HNSCC tumors that overexpress wild-type HRAS (wtHRAS^ov) and their response to chemotherapy is

SUBMITTER: Hoxhallari L 

PROVIDER: S-EPMC12183087 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature