Maternal and umbilical cord serum lipids in gestational diabetes predict offspring insulin secretion and resistance at the age of nine years.

ABSTRACT:

Introduction

Maternal metabolism in pregnancy is a major determinant of intrauterine milieu and is assumed to have long-term consequences in the offspring.

Objectives

To study whether maternal or cord serum lipids are related to measures of insulin resistance and β-cell function in childhood.

Methods

This is a secondary analysis of a previous trial in which women with newly diagnosed gestational diabetes were randomized to metformin versus insulin treatment. Maternal serum lipids were measured during pregnancy and umbilical cord serum lipids at delivery. Offspring insulin resistance and β-cell function were assessed at nine years of age using serum insulin, C-peptide, and glucose concentrations measured during an oral glucose tolerance test. A total of 122 mother-chil

SUBMITTER: Huhtala M 

PROVIDER: S-EPMC12183131 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature