Causal Relationship Between Diet, Lipids, Immune Cells, and Chronic Fatigue Syndrome: A Two-Mediation Mendelian Randomization Study.

ABSTRACT: Chronic fatigue syndrome (CFS) is a disorder characterized by severe unexplained fatigue and is associated with various factors including infections, immune responses, genetics, and environmental influences. However, the underlying mechanisms and possible interventions for CFS remain unclear. We used a two-mediated MR method to investigate causal relationships between diet, lipid levels, immune cells, and CFS. Our findings suggest that certain lipids, specifically low-density cholesterol, apolipoprotein E, and apolipoprotein B, contribute to CFS development. Conversely, high-density lipoprotein cholesterol and apolipoprotein A1 may delay the onset of the syndrome. Additionally, we explored how lipids affect fatigue through immune cell mediation. Factors, such as hematopoietic stem cell abs

SUBMITTER: Li J 

PROVIDER: S-EPMC12183343 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature