Multi-Omics Analysis Reveals Causal Relationships and Potential Mediators Between Dietary Preferences and Risk of NAFLD.

ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is a prevalent condition closely associated with obesity and metabolic syndrome, with its global incidence on the rise. This study aims to explore the causal relationship between dietary preferences and NAFLD risk using multi-omics analysis, and to comprehensively explore possible mediating factors and their underlying mechanisms. We analyzed data from genome-wide association studies (GWAS) to assess the potential genetic links between various dietary preferences and NAFLD. A two-step Mendelian randomization (MR) analysis was conducted to evaluate whether dietary preferences affect NAFLD risk by regulating inflammatory factors. Further, co-localization analysis was used to identify gene loci driving the causal relationships between dietary preferen

SUBMITTER: Fu Q 

PROVIDER: S-EPMC12183393 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature