Signalling <i>via</i> CD131 regulates pulmonary inflammation, alveolar cell death and emphysema in COPD.

ABSTRACT:

Background

COPD is a heterogenous disease where chronic inflammation is implicated in airway remodelling and emphysema. The CD131 receptor is indispensable for signalling by the β common (βc) family of cytokines encompassing granulocyte-macrophage colony-stimulating factor, interleukin (IL)-5 and IL-3, which instigate both type-2 and non-type-2 inflammatory responses. This study aims to determine whether antagonising CD131 signalling can prevent pulmonary inflammation, alveolar cell death and emphysema development.

Methods

We performed in-house and in silico transcriptomic analysis to investigate the gene expression of CD131 (CSF2RB) and pathway enrichment for βc cytokine signalling in blood, sputum and lung biopsies of COPD patients. To model emphysema, transg

SUBMITTER: Wang H 

PROVIDER: S-EPMC12183705 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature