Predicting prognosis and immunotherapy response of ferroptosis-related genes in colorectal cancer.

ABSTRACT: To identify ferroptosis markers, which were associated with prognosis and immune response in colorectal cancer (CRC), we integrated spatial transcriptome, single-cell transcriptome, and bulk transcriptome data for analysis, and this multi-omics integration approach is an innovation that distinguishes this study from previous ones. We assessed the prognostic value of ferroptosis-related genes by Kaplan-Meier survival analysis, subject operating characteristic (ROC) curves, and Lasso analysis. A total of 135 ferroptosis-associated genes were identified, with the high-risk subgroup having significantly worse overall survival. The prognostic model showed strong predictive power. Immunohistochemistry (IHC) assay showed that Sorting Nexin 5 (SNX5) and Ubiquitin-specific protease 7 (USP7) were si

SUBMITTER: Wei H 

PROVIDER: S-EPMC12183847 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature