Photobiomodulation mitigates blood-brain barrier disruption in APP/PS1 mouse model of Alzheimer's disease by activating the AMPK pathway.

ABSTRACT:

Background

Photobiomodulation (PBM), which utilizes specific light wavelengths to regulate cellular metabolism, signal transduction, and gene expression, has emerged as a promising intervention for enhancing cognitive function in Alzheimer's disease (AD). The blood-brain barrier (BBB) plays a critical role in protecting the central nervous system, and its dysfunction is a major contributor to AD pathogenesis. Although PBM has shown therapeutic potential, its effects on BBB integrity and the underlying mechanisms remain unclear.

Methods

Six-month-old female APP/PS1 transgenic mice were subjected to PBM intervention (808 nm, 20 mW/cm²) for six weeks. Cognitive function was assessed using behavioral tests, while biochemical and histological analyses were conducted to

SUBMITTER: Ma C 

PROVIDER: S-EPMC12183848 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature