Cold receptor TRPM8 as a target for migraine-associated pain and affective comorbidities.

ABSTRACT:

Background

Genetic variations in the Trpm8 gene that encodes the cold receptor TRPM8 have been linked to protection against polygenic migraine, a disabling condition primarily affecting women. Noteworthy, TRPM8 has been recently found in brain areas related to emotional processing, suggesting an unrecognized role in migraine comorbidities. Here, we use mouse behavioural models to investigate the role of Trpm8 in migraine-related phenotypes. Subsequently, we test the efficacy of rapamycin, a clinically relevant TRPM8 agonist, in these behavioural traits and in human induced pluripotent stem cell (iPSC)-derived sensory neurons.

Findings

We report that Trpm8 null mice exhibited impulsive and depressive-like behaviours, while also showing frequent pain-like facial expressions de

SUBMITTER: Cabanero D 

PROVIDER: S-EPMC12183901 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature