The interaction between circadian syndrome and genetic susceptibility in the risk of incident dementia: A longitudinal cohort study.

ABSTRACT:

Background

Despite growing interest in circadian disturbances as potential triggers for dementia, the specific impact of circadian syndrome (CircS) on dementia incidence remains poorly understood. Moreover, the role of genetic susceptibility modulating these effects remains to be explored.

Methods

Dementia-free participants from the UK Biobank cohort were included in the analysis. To evaluate the association between CircS and the incidence of dementia, as well as the modifying influence of genetic susceptibility on this relationship, Cox proportional hazards models were utilized.

Results

During a median follow-up period of 14.55 years, 3,965 incident dementia cases were documented. CircS was found to significantly increased the risk of incident dementia, with a hazard

SUBMITTER: Yu L 

PROVIDER: S-EPMC12183943 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature