Associations of ischemic heart disease with brain glymphatic MRI indices and risk of Alzheimer's disease.

ABSTRACT:

Background

The impact of ischemic heart disease (IHD) on the brain glymphatic MRI indices and risk of Alzheimer's disease (AD) remains largely unclear. This study aimed to investigate the associations between IHD, brain glymphatic MRI indices and risk of AD.

Methods

A total of 1385 non-dementia subjects (55.2 % male, mean age 73.53) were included. Diffusivity along the perivascular space (DTI-ALPS), free water (FW) and choroid plexus volume were used to reflect glymphatic function. The associations of IHD with MRI derived glymphatic indices, PET amyloid, tau and cognitive performance were explored by multiple regression analysis. IHD were tested as predictors of clinical progression using cox proportional hazards modeling. The mediation effect of MRI derived glymphatic indic

SUBMITTER: Wang ML 

PROVIDER: S-EPMC12183944 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature