Cardiovascular health, genetic predisposition, and dementia risk among atherosclerotic cardiovascular disease patients.

ABSTRACT:

Background

While optimal cardiovascular health (CVH) has been linked to a lower risk of dementia, few studies considered individuals' genetic background. We aimed to examine the interaction between CVH and genetic predisposition on dementia risk among individuals with atherosclerotic cardiovascular disease (ASCVD).

Methods

We included 30,818 ASCVD patients from the UK Biobank. CVH was assessed using Life's Essential 8, and genetic predisposition determined by a genetic risk score (GRS) incorporating 85 genetic variants. Cox proportional hazard models were used to estimate hazard ratios (HRs) for all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD).

Results

Over a median follow-up of 13.5 years, 1,360 cases of all-cause dementia were identified, in

SUBMITTER: Dai L 

PROVIDER: S-EPMC12183981 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature