The impact of pre-analytical factors on plasma biomarkers for Alzheimer's disease: The ASPREE Healthy Ageing Biobank.

ABSTRACT:

Background

The conditions under which samples were collected, processed, and stored in biobanks may influence Alzheimer's disease (AD) biomarker levels.

Objectives

This study aims to investigate whether a range of pre-analytical factors influence plasma levels of AD biomarkers.

Methods

Data were obtained from the ASPREE Healthy Ageing Biobank, a cohort of healthy community-dwelling older individuals aged 70+ years in Australia. Five biomarkers were measured using plasma from 11,868 individuals: phosphorylated-tau181 (p-tau181), neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and amyloid-beta 42 and 40 (Aβ42/Aβ40). Linear regression examined the association between pre-analytical factors and biomarker levels.

Results

Participants were ag

SUBMITTER: Wu Z 

PROVIDER: S-EPMC12183983 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature