Microstructural white matter injury contributes to cognitive decline: Besides amyloid and tau.

ABSTRACT:

Background

Cognitive decline and the progression to Alzheimer's disease (AD) are traditionally associated with amyloid-beta (Aβ) and tau pathologies. This study aims to evaluate the relationships between microstructural white matter injury, cognitive decline and AD core biomarkers.

Methods

We conducted a longitudinal study of 566 participants using peak width of skeletonized mean diffusivity (PSMD) to quantify microstructural white matter injury. The associations of PSMD with changes in cognitive functions, AD pathologies (Aβ, tau, and neurodegeneration), and volumes of AD-signature regions of interest (ROI) or hippocampus were estimated. The associations between PSMD and the incidences of clinical progression were also tested. Covariates included age, sex, education, apolip

SUBMITTER: Hu HY 

PROVIDER: S-EPMC12183991 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature