Association of statins use and genetic susceptibility with incidence of Alzheimer's disease.

ABSTRACT:

Background

The effect of statins use on the incidence of Alzheimer's disease (AD) is still under debate, and it could be modified by a series of factors.

Objectives

We aimed to examine the association of statins use with the risk of cognitive impairment and AD, and assess the moderating roles of genetic susceptibility and other individual-related factors.

Design

A longitudinal study was conducted from the UK Biobank where individuals completed baseline surveys (2006-2010) and were followed (mean follow-up period: 9 years).

Setting

A population-based study.

Participants

A total of 371,019 dementia-free participants (mean age 56.4 years; 53.6% female).

Measurements

The effects of statins use on cognitive performance and incident AD were examined by

SUBMITTER: Ye Z 

PROVIDER: S-EPMC12184001 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature