Plasma amyloid-β precursor protein _669-711/amyloid-β_1-42 ratio is associated with cognition in Alzheimer's disease.

ABSTRACT: Plasma amyloid-β (Aβ) markers are significant predictors of Aβ pathology. However, their prognostic value for cognition in patients with Alzheimer's disease (AD) is unknown. We compared plasma amyloid-β precursor protein (APP)_669-711 and Aβ_1-42 levels between cognitively unimpaired participants (CU) and those with MCI due to AD and AD dementia. The CU group was divided into CU+ or CU- groups according to presence of Aβ pathology. All patients with AD exhibited Aβ pathology. The plasma APP_669-711/Aβ_1-42 ratio was significantly elevated in patients with CU+, MCI+, and AD+ compared with those with CU-. Furthermore, the plasma APP_669-711/Aβ_1-42 ratio was significantly correlated with the MMSE score (rs = -0.544, p < 0.001). Anal

SUBMITTER: Noguchi-Shinohara M 

PROVIDER: S-EPMC12184047 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature