High Ultra-Processed Food Consumption Is Associated with Clinical Exacerbation in Patients with Crohn's Disease in Remission: A Prospective Cohort Study.

ABSTRACT:

Introduction

Diet can impact the clinical course of Crohn's disease (CD). However, the importance of food processing level is uncertain. We aimed to evaluate whether ultra-processed foods (UPFs) are associated with an increased risk of relapse among patients with CD in clinical remission.

Methods

In this prospective cohort study, adult patients with CD in clinical remission were followed for 1 year or until clinical relapse, as assessed by the Harvey Bradshaw index. Dietary intake was assessed using a food frequency questionnaire and a dedicated validated processed food questionnaire to evaluate UPF consumption. Multivariable Cox proportional hazard models were used to estimate the adjusted hazard ratio of disease relapse according to high or low UPF consumption.

Results<

SUBMITTER: Sarbagili-Shabat C 

PROVIDER: S-EPMC12185055 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature