Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview.

ABSTRACT:

Introduction

Neurofilament light chain (NfL) quantification aids in diagnosing and predicting neurological disorders, but clinical and laboratory practices vary across centers. Differences in result interpretation and reporting further challenge test commutability. This study aimed to review the global analytical and post-analytical methods used for NfL measurement in routine clinical practice across different contexts.

Methods

We established an international working group (WG) and distributed a survey to its members to gather information on context of use (COU), (pre) analytical methods, cutoff usage, as well as the interpretation and reporting of NfL measurements.

Results

Among the centers, 63% measured NfL in cerebrospinal fluid (CSF), 87% in blood, and 53% in both

SUBMITTER: Delaby C 

PROVIDER: S-EPMC12185249 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature