Altered tRNA expression profile associated with codon-specific proteomic changes in the suicide brain.

ABSTRACT: Suicide is a major public health concern, and the number of deaths by suicide has been increasing in recent years in the US. There are various biological risk factors for suicide, but causal molecular mechanisms remain unknown, suggesting that investigation of novel mechanisms and integrative approaches are necessary. Transfer (t)RNAs and their modifications, including cytosine methylation (m⁵C), have received little attention regarding their role in normal or diseased brain function, though they are dynamic mediators of protein synthesis. tRNA regulation is highly interconnected with proteomic and metabolomic outcomes, suggesting that investigating these multiple levels of molecular regulation together may elucidate more information on neural function and suicide risk. In the c

SUBMITTER: Blaze J 

PROVIDER: S-EPMC12185327 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature