MYO1G promoter hypomethylation correlates with its mRNA expression, lymphocyte infiltration, and immunotherapy response in melanoma.

ABSTRACT:

Objectives

Myosin IG (MYO1G) plays a vital role in triggering an immune response via regulating T cell migration to detect antigen-presenting cells. However, the biological and clinical significance of MYO1G DNA methylation and gene expression in melanoma and its immune microenvironment remains unknown.

Materials and methods

We investigated and corroborated the correlations of MYO1G DNA methylation with gene expression, and clinicopathologic parameters in 461 melanomas from The Cancer Genome Atlas (TCGA). Subsequently, we associated MYO1G gene expression with overall survival in two independent cohorts including 94 immunotherapy-treated melanoma patients and 54 stage IV melanoma patients, respectively. Finally, the quantitative methylation-specifi

SUBMITTER: Xia Y 

PROVIDER: S-EPMC12185404 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature