Common genetic variation associated with adult subcortical brain volume is also associated with subcortical brain volume at birth.

ABSTRACT:

Introduction

Recent genome-wide association studies have identified numerous single nucleotide polymorphisms (SNPs) associated with subcortical brain volumes. These studies have been undertaken in largely adult cohorts. In this work we explore the role of common genetic variability in fetal and perinatal brain development. We investigate how genetic variation, known to be associated with adult subcortical brain volume, affects the infant subcortical brain.

Methods

We examine the influence of specific genetic loci and genome-wide polygenic scores on development of the fetal brain. Using a cohort of 208 term-born infants from the Developing Human Connectome Project, we ask whether eight SNPs, previously associated with adult subcortical brain volumes, show similar associations

SUBMITTER: Cullen H 

PROVIDER: S-EPMC12185412 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature