Comprehensive regional study of ESBL <i>Escherichia coli</i>: genomic insights into antimicrobial resistance and inter-source dissemination of ESBL genes.

ABSTRACT:

Introduction

The global dissemination of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (E. coli) poses a significant public health challenge, particularly in regions with high antimicrobial resistance (AMR) occurrence. This study investigated the occurrence, genomic characteristics, and dissemination dynamics of ESBL-producing E. coli in Abruzzo, Italy, by analyzing 956 isolates from humans, livestock, wildlife, and food products.

Methods

Phenotypic and genomic analyses were performed on the isolates to assess ESBL-E. coli occurrence and characteristics. Multilocus sequence typing (MLST) was used to identify sequence types (STs), and plasmid profiling alongside synteny analysis was conducted to investigate horizontal gene transfe

SUBMITTER: Di Marcantonio L 

PROVIDER: S-EPMC12185426 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature