Change in resuscitation influenced development and severity of inflammatory complications in severely injured.

ABSTRACT:

Introduction

Resuscitation strategies for severely injured patients have shifted toward reduced crystalloids and increased balanced blood product resuscitation, including Fresh Frozen Plasma (FFP) to reduce organ failure and mortality. However, FFP is associated with higher infection and sepsis risks. This study investigated the impact of resuscitation changes on inflammatory complications and mortality.

Methods

This 11-year cohort study included severely injured patients (> 15 years) admitted to a Level-1 Trauma Center ICU. Exclusions included isolated head injuries, drowning, asphyxiation, burns, and deaths < 48 h. Data on demographics, resuscitation, inflammatory complications (MODS, ARDS, infections, thromboembolism), and mortality were collected.

Results

Among 58

SUBMITTER: van Wessem KJP 

PROVIDER: S-EPMC12185553 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature