CD18 and CD36 expression in neutrophils from tumors and tumor-draining lymph nodes: implications for metastasis in oral squamous cell carcinoma.

ABSTRACT:

Background

Neutrophil infiltration in tumors and tumor-draining lymph nodes (TDLNs) influences oral squamous cell carcinoma (OSCC) progression and metastasis. Neutrophils can exhibit an immunosuppressive phenotype, with CD18 and CD36 potentially linked to this. This study characterizes CD18/CD36 expression on neutrophils from different OSCC microenvironments and their association with metastasis.

Methods

We assessed CD18 and CD36 expression on neutrophils from OSCC tumors, TDLNs, and healthy lymph nodes using flow cytometry. We also examined whether co-culture with the CAL27 oral cancer cell line influenced CD18/CD36 expression in blood neutrophils from healthy donors.

Results

Neutrophils from OSCC tumors and TDLNs exhibited higher CD18 expression than those from heal

SUBMITTER: Ekstedt S 

PROVIDER: S-EPMC12185613 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature