Extension and validation of a physiologically based toxicokinetic model for risk assessment of aluminium exposure in humans.

ABSTRACT: The safety of aluminium (Al) exposure from sources such as food, parenteral nutrition or adjuvanted medicinal products is still a matter of uncertainty. Since toxicokinetic studies in humans are lacking, model predictions are warranted for risk assessment. Recently, we established a physiologically based toxicokinetic (PBTK) model for Al built on a comprehensive toxicokinetic 26Al database, which could describe Al biokinetics in rats and human adults after single oral and intravenous doses of soluble Al salts. Since then, we have substantially amended the model, rendering it applicable to accurately represent children and their dynamically changing physiology (including maturating renal function in neonates and increased bone turnover during puberty). Also, additional sources of exposure w

SUBMITTER: Hartung N 

PROVIDER: S-EPMC12185619 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature