Sea cucumber sulfated polysaccharides extract potentiates the anticancer effect of 5- fluorouracil on hepatocellular carcinoma cells.

ABSTRACT: Sea cucumber represents a potential marine source of high value compounds with medicinal properties especially its anti-cancer activity. Sea cucumbers contain numerous biomolecules, including sulfated polysaccharides (Ps) which have enormous therapeutic and nutraceutical potential. This study aimed to investigate anticancer effect of Ps extracted from sea cucumbers on hepatocellular carcinoma. This study was in vitro study conducted on HepG-2 cells and normal wish cells that were divided into four groups: Group I including untreated cells, Group II including cells treated with different concentrations of 5-FU, Group III including cells treated with various concentrations of Ps extract. Group IV including cells treated with different concentrations of combined 5-FU and Ps extract. The extra

SUBMITTER: Ismail SE 

PROVIDER: S-EPMC12185687 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature