Safety and efficacy of live attenuated PEDV vaccines for neonatal protection.

ABSTRACT: Porcine epidemic diarrhea virus (PEDV) causes severe diarrheal disease with high mortality in neonatal piglets. To protect suckling piglets, maternal vaccination strategies that induce lactogenic immunity in sows are crucial. To develop modified live vaccine candidates, we generated recombinant viruses with genome alterations such as deletion of the ORF3 accessory gene (ΔORF3), deletion of the N-terminal sialic acid binding domain of the spike glycoprotein (S^ΔN), and rearrangement of the spike, envelope, matrix and nucleocapsid genes (SEMN → ESMN) in the viral genome. These recombinant PEDVs were evaluated for their safety, virulence and immunogenicity in neonatal piglets. Piglets infected with the parental virus exhibited severe diarrhea and high mortality. Deletion of ORF3 alo

SUBMITTER: Li W 

PROVIDER: S-EPMC12185690 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature