Multifaceted biomedical applications of biogenic titanium dioxide nanoparticles fabricated by marine actinobacterium Streptomyces vinaceusdrappus AMG31.

ABSTRACT: The biomass filtrate of marine actinobacterium, Streptomyces vinaceusdrappus AMG31, was utilized as a biocompatible and biocatalyst for titanium dioxide nanoparticles (TiO₂-NPs) synthesis. Characterization revealed well-dispersed, spherical structures with high crystallinity in the anatase phase, with sizes from 10 to 50 nm. The biosynthesized TiO₂-NPs demonstrated potent antioxidant activity with maximum DPPH and ABTS radical scavenging percentages of 94.6% and 88.2% at 1000 µg/ml, with IC₅₀ values of 11.1 and 14.36 µg/ml, respectively. TiO₂-NPs exhibited moderate wound healing activity with 66.6% wound closure compared to controls (62.6%) after 48 h. The hemocompatibility assessment revealed minimal hemolytic activity (1.9% at 1000 µg/ml) and modest anticoagulant effects in PT (14.2 s) a

SUBMITTER: Ghareeb A 

PROVIDER: S-EPMC12185696 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature