CLPTM1L interacts with ERLIN2 to stabilize SREBP1 and drive tumorigenesis in nasopharyngeal carcinoma.

ABSTRACT: CLPTM1L has been identified as a susceptibility gene associated with nasopharyngeal carcinoma (NPC) risk, but its biological function and underlying mechanisms remain unclear. Here, we demonstrate that CLPTM1L is highly expressed in NPC patients and is associated with poor prognosis. Functional assays reveal that CLPTM1L overexpression significantly enhances NPC cell proliferation, migration and invasion, whereas its knockdown induces apoptosis and suppresses tumor growth. We further uncover that the transcription factor KLF1 directly binds to the promoter of CLPTM1L, driving its transcriptional activation. Transcriptome analysis indicates that CLPTM1L regulates various lipid metabolic pathways, notably upregulating SREBP1, a key metabolic regulator, thereby increasing intracellular free f

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12185749 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature