Physiology, imaging and proteomics of non-ventilated vs. non-perfused lung injury: an experimental study.

ABSTRACT:

Background

The exclusion of one lung from ventilation or pulmonary artery perfusion triggers pathological mechanisms that can lead to lung injury. Although the final effect is similar for both insults, the underlying mechanisms may differ. Primary aim of this study was to compare severity of lung injury between non-ventilated (NVLI) and non-perfused (NPLI) lung injury. Secondary aims were to compare physiologic, imaging and proteomic signatures of NVLI vs NPLI.

Methods

Sedated and paralyzed healthy female piglets (weight = 36 ± 5 kg) were mechanically ventilated for 24 h after left pulmonary artery ligation (NPLI group, n = 11) or exclusion from ventilation of the left lung (NVLI group, n = 10). Physiological data including electrical impedance tomography imaging of regional

SUBMITTER: Damia A 

PROVIDER: S-EPMC12185848 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature