Genetic Variations in GCKR and PNPLA3 Regulate Metabolic Balance Across the Liver.

ABSTRACT: We tested genetic variants in GCK, GCKR, and PNPLA3 in a large sample of self-identified Mexican Americans from the BetaGene Study for association with type 2 diabetes-related phenotypes under the hypothesis that they may regulate metabolic balance across the liver and contribute to hepatic steatosis and insulin resistance. We further tested whether interactions with dietary fructose and total sugar contributes to the observed associations. GCK rs1799831 was not associated with any type 2 diabetes-related phenotypes either alone or with any interaction tested. We replicated previous associations reported for GCKR rs780094 and PNPLA3 rs738409. We also show the interaction between GCKR rs780094 and dietary fructose is associated with both glucose effectiveness and glucose effectiveness at ze

SUBMITTER: Ma Y 

PROVIDER: S-EPMC12185970 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature