Evaluation of Beauvericin's activity and mode of action against all life stages of <i>L. tropica</i> for cutaneous Leishmaniasis therapy.

ABSTRACT:

Background

Leishmaniasis, particularly its cutaneous form caused by Leishmania tropica, remains a significant global health concern due to the limitations of current treatments, including drug resistance, toxicity, and inconsistent efficacy. This study investigates the potential of Beauvericin (BEA), a fungal secondary metabolite, as an alternative antileishmanial agent.

Objectives

This study investigates the potential of Beauvericin (BEA), a fungal secondary metabolite, as an alternative antileishmanial agent.

Methods

We assessed the efficacy of BEA against different developmental stages of L. tropica using in vitro assays and an in vivo Galleria mellonella infection model. The ability of L. tropica to develop resistance to BEA and

SUBMITTER: Al Samra L 

PROVIDER: S-EPMC12185981 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature