A pyrimidine metabolism-related gene signature for prognosis prediction and immune microenvironment description of breast cancer.

ABSTRACT:

Background

Metabolic reprogramming is a hallmark in cancer. Pyrimidine metabolism (PM), a part of nucleotide metabolism, has been shown to be associated with the progression of various cancers, and the prognostic predictive ability of pyrimidine metabolism-related genes (PMG) in breast cancer has not been elucidated. This paper was designed to identify pyrimidine metabolism-related prognostic marker of breast cancer and potential targeted therapeutic options.

Methods

The cohort in the TCGA-BRCA dataset was used for patient information, and 108 pyrimidine metabolism-related genes were identified from the MSigDB KEGG pathways. We identified PM clusters in breast cancer and established a PM risk score model based on 10 pyrimidine metabolism-related genes. The status of immune i

SUBMITTER: Wang H 

PROVIDER: S-EPMC12186316 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature