Genomic characterization and virulence of Streptococcus suis serotype 7 sequence type 373 of clonal complex 94.

ABSTRACT: Streptococcus suis is a swine pathogen that also causes invasive infections in humans, leading to significant economic losses in pig production worldwide. Serotype 2 is the most pathogenic S. suis strain associated with human infections. However, non-serotype 2 strains isolated from humans have been reported globally. Here, we conducted a comparative genomic analysis of S. suis serotype 7-ST373 strains belonging to clonal complex 94, isolated from both humans and pigs, and assessed their virulence through mouse infection experiments. Genomic analysis revealed that S. suis serotype 7-ST373 strains harbor genomic islands 1-3 of the pathogenic S. suis clade. They also possess a high number of virulence-associated genes, similar to those of virulent serotype 2 strains, suggesting a high virule

SUBMITTER: Hatrongjit R 

PROVIDER: S-EPMC12186334 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature