A deoxynucleoside triphosphate triphosphohydrolase promotes cell cycle progression in <i>Caulobacter crescentus</i>.

ABSTRACT: Intracellular pools of deoxynucleoside triphosphates (dNTPs) are strictly maintained throughout the cell cycle to ensure accurate and efficient DNA replication. DNA synthesis requires an abundance of dNTPs, but elevated dNTP concentrations in nonreplicating cells delay entry into S phase. Enzymes known as deoxyguanosine triphosphate triphosphohydrolases (Dgts) hydrolyze dNTPs into deoxynucleosides and triphosphates, and we propose that Dgts restrict dNTP concentrations to promote the G1 to S phase transition. We characterized a Dgt from the bacterium Caulobacter crescentus termed flagellar signaling suppressor C (fssC) to clarify the role of Dgts in cell cycle regulation. Deleting fssC increases dNTP levels and extends the G1 phase of the cell cycle through a me

SUBMITTER: Hellenbrand CN 

PROVIDER: S-EPMC12186491 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature