Genome-scale metabolic modeling reveals specific vaginal <i>Lactobacillus</i> strains and their metabolites as key inhibitors of <i>Candida albicans</i>.

ABSTRACT: As the predominant constituents of the vaginal microbiome in healthy women, Lactobacillus species are considered essential in maintaining a homeostatic vaginal microbiome. Specific Lactobacillus species can produce beneficial metabolites to support their persistence within the host environment and inhibit Candida albicans colonization. Due to the extensive diversity of Lactobacillus species and their metabolites, comprehensively investigating all possible interactions remains challenging. This study employed an integrative approach combining genome-scale metabolic modeling, metagenomic sequencing, and in vitro validation to explore Lactobacillus and C. albicans interactions. Pairwise simulations of 159 Lactobacillus strains with C.

SUBMITTER: Hu T 

PROVIDER: S-EPMC12186704 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature