A new P3N ligand for Pd-catalyzed cross-couplings in water.

ABSTRACT: A new "P3N" ligand, (n-Bu₂N)₃P, derived from PCl₃ and three equivalents of n-Bu₂NH is reported. When complexed to palladium, it readily participates in homogeneous (copper-free) Heck-Cassar-Sonogashira and Suzuki-Miyaura couplings. Reliance on relatively low loadings of Pd is documented under aqueous micellar conditions; i.e., in water containing micelles using the well-established and inexpensive anionic surfactant SDS. Comparisons are shown with several commonly used, representative ligands which, by contrast, are made typically in a number of steps that involve environmentally egregious conditions, and can typically be quite expensive. These issues can now be avoided for these very important reactions using this P3N ligand

SUBMITTER: Oftadeh E 

PROVIDER: S-EPMC12186811 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature