Targeted Normoxemia and Supplemental Oxygen-Free Days in Critically Injured Adults: A Stepped-Wedge Cluster Randomized Clinical Trial.

ABSTRACT:

Importance

Supplemental oxygen is fundamental to caring for critically injured adults but can expose them to excess inspired oxygen.

Objective

To determine the safety and effectiveness of targeting normoxemia in critically ill trauma patients.

Design, setting, and participants

This multicenter, stepped-wedge, cluster randomized clinical trial compared targeted normoxemia (defined as a peripheral oxygen saturation [Spo2] of 90% to 96%) with usual care among adult trauma patients admitted to an intensive care unit (ICU) at 8 level I trauma centers across the US. These trauma centers were randomized at 3-month intervals when they crossed over from usual care to targeting normoxemia. Eligible patients were enrolled between July 15, 2020, and November 14, 2022. All statist

SUBMITTER: Douin DJ 

PROVIDER: S-EPMC12186824 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature