The Risk of Decompensation in Steatotic Liver Disease-Related Hepatocellular Carcinoma: A Comparison with Viral-Controlled Cases.

ABSTRACT:

Background and aims

Treatment options for steatotic liver disease (SLD) are limited compared to those for viral hepatitis, which may affect the prognosis of patients with hepatocellular carcinoma (HCC).

Methods

This retrospective cohort study included 255 and 125 patients with SLD-related HCC and viral-controlled HCC (80 hepatitis C and 45 hepatitis B) who underwent curative radiofrequency ablation (RFA) for primary HCC (maximum tumor diameter ≤3 cm and ≤3 lesions). Viral control was defined as a sustained virological response to hepatitis C and undetectable hepatitis B viruses on a nucleos(t)ide analog before HCC diagnosis. Overall survival, recurrence rates, and hepatic decompensation rates were evaluated using the Kaplan-Meier method and Cox proportional hazard models bet

SUBMITTER: Matsushita Y 

PROVIDER: S-EPMC12186850 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature