Genetic markers for knee osteoarthritis presence are not associated with disease progression - data from the IMI-APPROACH cohort.

ABSTRACT:

Objective

Knee osteoarthritis (OA) is a heterogeneous disease with different endotypes and phenotypes, resulting in patients' varying clinical and structural progression. Several genomic markers have been associated with knee OA presence. This study aimed to find new associations of these genetic markers with knee OA progression and to investigate the risk of knee OA progression using a polygenic risk score (PRS).

Methods

Data from knee OA patients (n = 297) from the IMI-APPROACH cohort with detailed measurements on disease progression were used. Knee OA progression definitions were based on the decrease in minimum joint space width in mm (minJSW; primary outcome), increase in pain on the Knee injury and Osteoarthritis Outcome Score (KOOS), and presence of radiographic OA (b

SUBMITTER: Bentvelzen MLM 

PROVIDER: S-EPMC12186935 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature