"We have to amplify what we saw at EBOVAC" - Assessing participant perceptions, attitudes, and acceptability of an ancillary care policy in an Ebola vaccine trial in the Democratic Republic of the Congo: A mixed methods study.

ABSTRACT:

Introduction

In a vaccine trial conducted between 2019 and 2022 in Boende, a remote, resource-constrained area of the Democratic Republic of the Congo, our research team developed an ancillary care (AC) policy to provide adequate care and follow-up for concomitant adverse events (AE), whether study-related or not. The trial aimed to assess the safety and immunogenicity of an Ebola vaccine regimen among approximately 700 healthcare providers and frontliners to strengthen outbreak preparedness in this Ebola-endemic region, where access to healthcare is severely limited by poverty, weak infrastructure, and an overstretched health system.

Methods

A mixed-methods approach was used to assess participants' acceptability of the AC policy. First, participants with AE completed a ques

SUBMITTER: Lemey G 

PROVIDER: S-EPMC12186984 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature