Higher-Order Intrinsic Brain Network Trajectories After Antipsychotic Treatment in Medication-Naive Patients With First-Episode Psychosis.

ABSTRACT:

Background

Intrinsic brain network connectivity is already altered in first-episode psychosis (FEP), but the longitudinal trajectories of network connectivity, especially in response to antipsychotic treatment, remain poorly understood. The goal of this study was to investigate how antipsychotic medications affect higher-order intrinsic brain network connectivity in FEP.

Methods

Data from 87 antipsychotic medication-naïve patients with FEP and 87 healthy control participants were used. Medication-naïve patients received antipsychotic treatment for 16 weeks. Resting-state functional connectivity (FC) of the default mode, salience, dorsal attention, and executive control networks were assessed prior to treatment and at 6 and 16 weeks after treatment. We evaluated baseline and

SUBMITTER: Maximo JO 

PROVIDER: S-EPMC12187160 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature