Systemic inflammatory regulators and heart failure: A bidirectional 2-sample Mendelian randomization study.

ABSTRACT: The causal relationship between systemic inflammation and heart failure (HF) remains controversial, with unresolved questions about whether inflammatory dysregulation is a driver or consequence of HF pathogenesis. To evaluate bidirectional causal associations between systemic inflammatory regulators and HF using Mendelian randomization (MR). The genetic association with HF came from the largest and most recent genome-wide association study (cases and proxy cases: 47,309; Control: 9,30,014), as well as inflammatory regulators from the nearest cytokine genome-wide association study. Estimates were obtained by inverse variance weighting using the sensitivity analysis of MR-Egger, weighted median and MR-PRESSO. Three of the 41 systemic inflammatory regulators were associated with the risk of H

SUBMITTER: Lin G 

PROVIDER: S-EPMC12187285 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature