Causal relationship between air pollution and rheumatoid arthritis: A two-sample Mendelian randomization study.

ABSTRACT: Recent studies have highlighted potential links between air pollution and autoimmune diseases. However, the causal relationship between air pollution (including PM2.5, PM10, nitrogen dioxide, and nitrogen oxides) and rheumatoid arthritis (RA) remains unclear. To address this, we performed a two-sample Mendelian randomization (MR) analysis to assess the causal effects of air pollution on RA. Genome-wide association study data for air pollution metrics were utilized as exposures, while RA outcome data were sourced from European cohorts. Inverse variance weighting served as the primary method for causal estimation, supplemented by sensitivity analyses including weighted median, MR-Egger, weighted mode, and Bayesian weighted MR. All analyses were conducted using R software. Results from the in

SUBMITTER: Yang C 

PROVIDER: S-EPMC12187290 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature