Construction of an immune-related prognostic model and functional analysis of CEBPB in uveal melanoma: A STROBE-compliant observational study.

ABSTRACT: Uveal melanoma (UM) is a primary intraocular malignancy with a high-risk of metastasis. Currently, there are no studies that construct prognostic models based on immune-related molecular subtypes. We performed unsupervised clustering of immune cell infiltration matrices based on the the cancer genome atlas-uveal melanoma (TCGA-UVM) dataset, identifying 2 clusters with distinct expression patterns of immune checkpoint and immune activation related genes. gene ontology/Kyoto Encyclopedia of Genes and Genomes enrichment analysis revealed that genes in the immune-related gene modules identified by WGCNA were associated with immune activity and cell proliferation. Using Cox and LASSO regression analysis based on the immune-related gene modules to construct a prognostic model. The prognostic mod

SUBMITTER: Tao Y 

PROVIDER: S-EPMC12187318 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature