Functional germline variants in DNA damage repair pathways are associated with altered survival in adults with glioma treated with temozolomide.

ABSTRACT:

Background

Temozolomide (TMZ) treatment has demonstrated a variable impact on glioma prognosis. This study examines associations of survival with DNA repair gene germline polymorphisms among glioma patients who did and did not have TMZ treatment. Identifying genetic markers which sensitize tumor cells to TMZ could personalize therapy and improve outcomes.

Methods

We evaluated TMZ-related survival associations of pathogenic germline SNPs and genetically predicted transcript levels within 34 DNA repair genes among 1504 glioma patients from the University of California San Francisco Adult Glioma Study (UCSF AGS) and Mayo Clinic, whose diagnoses spanned pre- and post-TMZ eras within the major known glioma prognostic molecular subtypes.

Results

Among those who received TMZ

SUBMITTER: Guerra G 

PROVIDER: S-EPMC12187373 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature